CLINICAL APPLICATION OF PLASMA PROTEIN C DETERMINATION

Objective: Protein C, a vitamin K-dependent coagulation factor, is involved in blood coagulation. Activated protein C inactivates Va and VIIIa stimulates fibrinolysis. In this process, S serve as an important factor for activated C. Furthermore, excess drives cancer cell proliferation survival through oncogenic receptor Axl(Anexelekto). We determined ranges of both healthy individuals distinct hospitalized patients.
 Methods: A total 100 patients with different diagnostic diseases 50 were included their plasma determination. rabbit antibody against human was used the quantitative estimation antigen by using rocket immunoassay.
 Results: (PC:Ag) o.6439- 1.4752 µ/ml. The mean coefficient variation (CV) length calculated to be 12.45%. PC:Ag within laboratory 11.47%. Plasma destroyed at 56℃ 30 minutes, whereas no significant decrease found 4℃ refrigerator one week.
 Conclusion: results showed that considerably high 22 diabetes mellitus. On other hand, significantly decreased 19 liver cirrhosis(p< 0.001) positively correlation serum albumin levels(p< 0.05). 20 acute leukemias, on average,there slightly lower values PC:Ag, accompanied 5 M5 subtype 9 hyper- leukocytes leukemias. However, 3 promyelocytic leukemia (APL) overt picture DIC(disseminated intravascular coagulation) had concentration than remaining 2 infectious DIC, which suggested coagulopathy APL might due mechanisms from forms DIC.
 
 Peer Review History: Received 17 November 2020; Revised 12 Decembe; Accepted 1 January, Available online 15 January 2021
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 file: Comments reviewer(s): Average marks initial stage: 5.5/10
 publication 7.5/10
 Reviewer(s) detail:
 Dr. Idoko Alexander, Caritas University, Enugu, Nigeria, [email protected]
 Rawaa Souhil Al-Kayali, Aleppo Syria, [email protected]
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